Elisa Oppici Selected Research

Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)

4/2021	Dimerization Drives Proper Folding of Human Alanine:Glyoxylate Aminotransferase But Is Dispensable for Peroxisomal Targeting.
1/2018	Folding Defects Leading to Primary Hyperoxaluria.
1/2018	Correlation between the molecular effects of mutations at the dimer interface of alanine-glyoxylate aminotransferase leading to primary hyperoxaluria type I and the cellular response to vitamin B6.
1/2017	Use of polymer conjugates for the intraperoxisomal delivery of engineered human alanine:glyoxylate aminotransferase as a protein therapy for primary hyperoxaluria type I.
1/2016	Caenorhabditis elegans AGXT-1 is a mitochondrial and temperature-adapted ortholog of peroxisomal human AGT1: New insights into between-species divergence in glyoxylate metabolism.
1/2016	Natural and Unnatural Compounds Rescue Folding Defects of Human Alanine: Glyoxylate Aminotransferase Leading to Primary Hyperoxaluria Type I.
10/2015	The Chaperoning Activity of Amino-oxyacetic Acid on Folding-Defective Variants of Human Alanine:Glyoxylate Aminotransferase Causing Primary Hyperoxaluria Type I.
10/2015	Pyridoxamine and pyridoxal are more effective than pyridoxine in rescuing folding-defective variants of human alanine:glyoxylate aminotransferase causing primary hyperoxaluria type I.
9/2015	Liver peroxisomal alanine:glyoxylate aminotransferase and the effects of mutations associated with Primary Hyperoxaluria Type I: An overview.
11/2014	S81L and G170R mutations causing Primary Hyperoxaluria type I in homozygosis and heterozygosis: an example of positive interallelic complementation.

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Elisa Oppici Research Topics

Disease

16	Primary Hyperoxaluria (Oxaluria, Primary) 04/2021 - 02/2010
4	Rare Diseases (Rare Disease) 01/2018 - 02/2014
3	Neoplasms (Cancer) 01/2019 - 01/2016
3	Primary hyperoxaluria type 1 01/2016 - 01/2012
2	Hyperoxaluria (Oxaluria) 02/2019 - 01/2019
1	Amyloidosis 01/2019
1	Cone-Rod Dystrophies 12/2018
1	Proteostasis Deficiencies 01/2018
1	Stroke (Strokes) 10/2016
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2016
1	Breast Neoplasms (Breast Cancer) 01/2016
1	Hydroxykynureninuria 02/2014
1	Gyrate Atrophy 02/2014
1	Homocystinuria 02/2014
1	Aromatic amino acid decarboxylase deficiency 04/2013
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2012
1	Parkinson Disease (Parkinson's Disease) 01/2012
1	Tremor (Tremors) 01/2012
1	Hypokinesia (Bradykinesia) 01/2012
1	Nervous System Diseases (Neurological Disorders) 01/2012

Drug/Important Bio-Agent (IBA)

15	Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)IBA 04/2021 - 02/2010
11	EnzymesIBA 04/2021 - 01/2012
7	PyridoxalIBA 04/2021 - 01/2012
6	Proteins (Proteins, Gene)FDA Link 04/2021 - 10/2015
6	glyoxylic acid (glyoxylate)IBA 02/2019 - 01/2012
4	Calcium OxalateIBA 02/2019 - 12/2013
3	OxalatesIBA 02/2019 - 01/2016
3	Pyridoxine (Pyridoxin)FDA LinkGeneric 10/2015 - 04/2013
2	Vitamin B 6IBA 01/2018 - 10/2015
2	Coenzymes (Enzyme Cofactors)IBA 02/2014 - 08/2013
1	Prealbumin (Transthyretin)IBA 01/2019
1	CalciumIBA 12/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2018
1	Protein Isoforms (Isoforms)IBA 10/2018
1	Hydroxypyruvate ReductaseIBA 01/2018
1	glyoxylate reductaseIBA 01/2018
1	4-hydroxy-2-oxoglutarate aldolaseIBA 01/2018
1	PolymersIBA 01/2017
1	HomoarginineIBA 10/2016
1	Everolimus FDA Link 01/2016
1	AcidsIBA 10/2015
1	PyridoxamineIBA 10/2015
1	Pyridoxal Phosphate (Pyridoxal 5 Phosphate)IBA 10/2015
1	Alanine (L-Alanine)FDA Link 08/2013
1	Transaminases (Aminotransferases)IBA 08/2013
1	Aromatic-L-Amino-Acid DecarboxylasesIBA 01/2012
1	Serotonin (5 Hydroxytryptamine)IBA 01/2012
1	Dopamine (Intropin)FDA LinkGeneric 01/2012
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 02/2010

Therapy/Procedure

2	Therapeutics 01/2017 - 10/2015